#Infected burn series
Wound healing is a complex process involving a series of overlapping cellular and biochemical events orchestrated to restore tissue integrity after injury. 16, 17 Despite the development of improved burn patient care, many problems for burn patients are associated with the healing process. 12–15 Tigecycline is a new glycylcycline, a tetracycline derivative, with an extended broad-spectrum antibiotic action that includes the inhibition of Gram-positive, Gram-negative, atypical, anaerobic and antibiotic-resistant organisms.
11 In particular, the introduction of tigecycline has represented a promising effective therapy for infections caused by Gram-positive burn wound pathogens. 10 The continuously emerging resistance against existing drugs underlines the importance of the development of new antibiotics. At this time, no antibiotic class is uniformly effective against S. 1, 9 For this reason, these infections are responsible for significant human mortality and morbidity, and often result in prolonged hospital stays and/or increased healthcare costs. aureus (MRSA) colonization and infection.
#Infected burn skin
3, 5–7 Moreover, the disruption of the normal skin barrier, the immunocompromised state, 3, 6, 8 prolonged hospitalization and antibiotic therapy are risk factors for the development of methicillin-resistant S. aureus from the burn wound sites into distant organs via the bloodstream. 2–4 A burn wound can be regarded as a culture medium and the avascularity of the wound prevents the action of the blood-borne immune system, predisposing patients to a rapid dissemination of S. aureus is a part of the normal flora of human skin. Staphylococcus aureus is known to be a major cause of morbidity and death in burn patients, who can import or acquire staphylococci contaminating the environment and the hands of healthcare workers. In particular, a burn wound represents a susceptible site for opportunistic colonization by organisms of endogenous and exogenous origin. Patients treated at burn centres present a number of complications, including immunosuppression, sepsis and delayed wound healing. MMP-9, teicoplanin, animal models, methicillin-resistant Staphylococcus aureus Introduction
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